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Cymanquines: Metallo-Chloroquine Therapeutics
Inhibition of autophagy has become an attractive target for the clinical management of drug resistant cancers. Towards this end, the potent anti-malarial chloroquine (CQ) has been explored as an autophagy inhibitor in multiple studies. Unfortunately, CQ’s inability to exhibit cytotoxic effects in the low PH tumor microenvironment has presented...
Published: 2/25/2025
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Inventor(s): William Geiger, Kevin Lam, Claire Verschraegen, Jon Ramsey
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Piperazine Based Lead Compound for Cryptosporidium Reduces Both Diarrhea and Parasites
Cryptosporidiosis is a leading cause of life-threatening diarrhea for young children and immunocompromised people and Cryptosporidium parvum, one of the two main human Cryptosporidium pathogens, is also an important cause of diarrhea in dairy calves. Despite this impact on both human and animal health, the best available treatment of Cryptosporidium...
Published: 2/4/2025
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Inventor(s): Christopher Dwight Huston
Keywords(s):
Category(s): Technology Classifications > Agriculture, Technology Classifications > Biomedical
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Lupus (SLE) Diagnostic Biomarker and Therapeutic
Only one new drug has become available over the past 50 years for the estimated 1.5M Americans and 5M people worldwide suffering from systemic lupus erythematosus (SLE), also known as lupus. In addition, SLE is extremely challenging to diagnose, taking an average of 6 years to diagnosis from the first sign of symptoms, delaying critical early treatment....
Published: 2/25/2025
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Inventor(s): Iwona Buskiewicz, Andreas Koenig
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Identification of Aggressive Papillary Microcarcinomas of the Thyroid
Background:
The most common type of thyroid cancer is papillary thyroid cancer (PTC) and papillary microcarcinomas (PMC), PTC tumors of less than 1.0 cm, now account for about 40% of all PTC tumors. PMC tumors are thought to be relatively innocuous, however a PMC has an incidence of metastases of 20-50% and currently there is no ability to clearly...
Published: 2/25/2025
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Inventor(s): Frances Carr, Nikoletta Sidiropoulos
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Portable ECMO with Avian Lung Structure
Current available extracorporeal membrane oxidation (ECMO) units are expensive, not portable and leave patients confined to hospitals and requiring the care of highly trained personnel. With a growing number of end stage lung disease patients and those waiting for lung transplants, there is a critical unmet need for effective, economical and convenient...
Published: 2/25/2025
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Inventor(s): Daniel Weiss, Darcy Wagner, Sean Wrenn, Franziska Uhl, Ethan Griswold, Patrick Lee, Dryver Huston
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Interim Buprenorphine Treatment
Opioid addiction treatment through a portable device, combined with automated check-ins, in-person testing, and HIV/HepB education
Background:
Opioid addiction in American has hit epidemic levels and despite the demonstrated need for and the effectiveness of current treatments, waitlists persist. While waiting for treatments, patients are at high...
Published: 2/4/2025
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Inventor(s): Stacey Sigmon
Keywords(s):
Category(s): Technology Classifications > Biomedical
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FcγRIIa: A Novel Marker of Cardiovascular Risk
Increased platelet reactivity has been associated with a greater risk of cardiovascular events. Despite this consistent association, individualized anti-platelet therapy, guided by platelet function testing has not yet shown to reduce the risk of cardiovascular events and intra-individual variability of the current indirect platelet function tests has...
Published: 2/25/2025
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Inventor(s): David John Schneider*
Keywords(s):
Category(s): Technology Classifications > Biomedical
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PIP2 Treatment for Small Vessel Disease and Stroke
Functional and structural attenuations in the cerebral micro vascularization that are early culprits in the manifestations of SVDs
Background:
Cerebral small vessel diseases (SVD) are responsible for more than 25% of ischemic stroke and are a leading cause of age-related cognitive dementia and disability. Despite the enormous impact of SVDs on human...
Published: 2/25/2025
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Inventor(s): Mark Nelson, Fabrice Dabertrand, Osama Harraz, Masayo Koide
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Nanocage Sensors
The molecular nanocage concept can verify the purity and authenticity of agricultural products and could detect environmental contaminants
Background:
Increasing globalization and competition has created large economic incentives to commit food fraud by adding adulterants, fillers, or other inauthentic ingredients to agricultural products. Consequently,...
Published: 2/25/2025
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Inventor(s): Jianing Li, Severin Schneebeli, Mona Sharafi
Keywords(s):
Category(s): Technology Classifications > Agriculture, Technology Classifications > Biomedical
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Hemodialysis Filter Rotor
Heparin-free hemodialysis is usually obligatory in immediate post-operative states, bleeding diathesis and in critically ill patients. Conventionally, this is achieved through normal saline flushes and regional citrate anticoagulation, however, dialysis filters often clot requiring extra saline flushes and/or anticoagulation drugs, including, heparin....
Published: 2/25/2025
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Inventor(s): Macaulay Onuigbo
Keywords(s):
Category(s): Technology Classifications > Biomedical
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