<?xml version="1.0" encoding="utf-8"?><rss version="2.0"><channel><title>Latest technologies from University of Vermont (UVM)</title><link>http://uvm.technologypublisher.com</link><description>Be the first to know about the latest inventions and technologies available from University of Vermont (UVM)</description><language>en-US</language><pubDate>Thu, 05 Mar 2026 21:13:43 GMT</pubDate><lastBuildDate>Thu, 02 Oct 2025 08:52:05 GMT</lastBuildDate><docs>http://blogs.law.harvard.edu/tech/rss</docs><webMaster>UVMI.Case@uvm.edu</webMaster><copyright>Copyright 2026, University of Vermont (UVM)</copyright><item><title>CoreMarketplace</title><caseId>C0947</caseId><link>https://uvm.technologypublisher.com/techcase/C0947</link><description>Background

CoreMarketplace is an active international platform that enhances the visibility, citability, and reproducibility impact of research facilities through unique identifiers and dynamic publication tracking.

Technology Overview

CoreMarketplace (CM) is a global database hosting over 1,100 research facility homepages from 248 institutions, allowing detailed representation of staff, services, equipment, and publications. Each facility receives a unique and permanent Research Resource ID (RRID) to facilitate discovery and citation. The platform automates detection of publications citing...</description><pubDate>Thu, 02 Oct 2025 08:52:05 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0947</guid></item><item><title>Automated water sensing and sampling system</title><caseId>C0950</caseId><link>https://uvm.technologypublisher.com/techcase/C0950</link><description>This wireless drone can autonomously navigate a site, retrieve multiple water samples without cross contamination, sense multiple parameters of water quality in real-time, and integrate that information into a geophysical information system with minimal human operator intervention.

Technology Overview:

Water resources are an essential part of many industries, and monitoring water quality is necessary to ensure the continued health of the economy and ecosystem. This uncrewed aerial device integrates water parameter sensors, near-infrared multispectral cameras, a novel water sample collection ...</description><pubDate>Thu, 02 Oct 2025 08:46:23 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0950</guid></item><item><title>Omni-mission Healthcare Vehicle (OHV)</title><caseId>C0944</caseId><link>https://uvm.technologypublisher.com/techcase/C0944</link><description>A versatile healthcare solution designed to deliver specialized services to remote areas through a modular box truck.

Technology Overview

The Omni-mission Healthcare Vehicle (OHV) is a groundbreaking vehicle aimed at transforming mobile healthcare. It features a modular design that allows for the easy swap of healthcare equipment and furnishings to meet various medical service requirements. This innovation is particularly beneficial for health centers serving widespread patient demographics, especially in rural settings, offering a flexible and efficient alternative to traditional mobile uni...</description><pubDate>Thu, 04 Sep 2025 07:08:41 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0944</guid></item><item><title>Faster Output through Simplified Text Entry and Response (FOSTER)</title><caseId>C0967</caseId><link>https://uvm.technologypublisher.com/techcase/C0967</link><description>An advanced communication software for individuals with ALS speeds text-to-speech input times and makes generating speech easier, enables real-time conversation, and allows for more effective interpersonal interaction.

Technology Overview:

Many individuals with amyotrophic lateral sclerosis (ALS) or other disorders that impair speech rely on assistive technologies to communicate. These tools often use text-to-speech, with techniques like eye tracking used to input letters one at a time. To circumvent the problems caused by slow word and sentence construction, FOSTER uses a novel combination ...</description><pubDate>Tue, 26 Aug 2025 06:31:07 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0967</guid></item><item><title>App for Farm Biosecurity Mapping</title><caseId>C0943</caseId><link>https://uvm.technologypublisher.com/techcase/C0943</link><description>This easy-to-use software tool allows anyone with an internet connection to generate a standardized biosecurity premises map, without the need for costly or computationally intensive GIS applications.

Technology Overview:

By meeting Secure Food Supply requirements, dairy, beef, poultry, pork, and sheep industries can be better protected in case of an emergency animal disease outbreak. Developing a map alongside an enhanced biosecurity plan can facilitate rapid response to emergencies, and the maintenance of a stable food supply. This technology is an application tailored for the easy creatio...</description><pubDate>Tue, 26 Aug 2025 06:13:36 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0943</guid></item><item><title>An Economical In Situ System for Detecting Moisture</title><caseId>C0928</caseId><link>https://uvm.technologypublisher.com/techcase/C0928</link><description>This technology is an economical system for detecting and characterizing signal loss in communications channels with power at only one end of the channel. It is used to measure the properties of the medium itself, such as the amount of moisture.

Background:

One or more passive sensors can be embedded in situ during construction (at a point or in an array) in a substrate (such as the cement around bridge supports or rail bed foundation ballast) that acts as the channel medium. This system can be used to detect excess moisture levels that may hasten deterioration and structural failure in infr...</description><pubDate>Wed, 21 May 2025 11:49:15 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0928</guid></item><item><title>Embedded Railway Ballast Moisture Sensing</title><caseId>C0920</caseId><link>https://uvm.technologypublisher.com/techcase/C0920</link><description><![CDATA[Railbed health is an important aspect of safe transportation by train. If not properly maintained, over time this can lead to track misalignment and compromised load-bearing capacity. If the tracks are compromised in any way, catastrophic derailment is more likely. Additionally, the massive financial burden that misaligned tracks carry with them is a long-term expense that doesn&#39;t need to exist. Ballast are the rocks laid within the track. They provide vital stability that trains need to operate safely.

Our harmonic diode patches will be installed in every meter of the sub-ballast during ...]]></description><pubDate>Wed, 21 May 2025 11:48:14 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0920</guid></item><item><title>Vascular Integrity Preserved by “VasoPlex” Post Heart Attack</title><caseId>C0852</caseId><link>https://uvm.technologypublisher.com/techcase/C0852</link><description><![CDATA[A method of preserving cardiovascular integrity to limit long-term damage after myocardial infarction and other ischemic events

Background:

Compromised distal myocardial perfusion is commonly observed in 25-30% of patients with acute myocardial infarction (MI) despite action to restore blood flow in local lay vessels via thrombolytics and PCI/stenting. No treatments are currently available that preserve this vascular integrity after MI.

Technology Overview:

University of Vermont researchers have shown that treatment with a defined HGF/IgG complex, &ldquo;VasoPlex&rdquo; reduces infarct siz...]]></description><pubDate>Wed, 21 May 2025 10:05:19 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0852</guid></item><item><title>Knee Monitoring Device for Surgical Rehabilitation and Maximizing Sports Performance</title><caseId>C0838</caseId><link>https://uvm.technologypublisher.com/techcase/C0838</link><description><![CDATA[The system can be used to allow clinicians to monitor patients&rsquo; at-home progress and compliance with rehab protocols after knee surgery

Background:

Current technologies that can be deployed remotely only measure steps taken and/or range of motion to monitor post-surgical rehabilitation or performance. Technologies that can accurately measure muscle and joint loading are currently only available in laboratory-based settings such as optical motion capture, or are not realistically remotely deployable, in the case of systems that require large arrays of sensors.

Technology Overview:

Thi...]]></description><pubDate>Wed, 21 May 2025 10:03:58 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0838</guid></item><item><title>Hemodialysis Filter Rotor</title><caseId>C0834</caseId><link>https://uvm.technologypublisher.com/techcase/C0834</link><description>Heparin-free hemodialysis is usually obligatory in immediate post-operative states, bleeding diathesis and in critically ill patients. Conventionally, this is achieved through normal saline flushes and regional citrate anticoagulation, however, dialysis filters often clot requiring extra saline flushes and/or anticoagulation drugs, including, heparin. In addition, such maintenance prevents at home dialysis and disrupts the consistency of the treatment. 

To solve these problems, UVM researchers developed a hemodialysis filter rotor, that rotates the hemodialysis filter, via a programmable rota...</description><pubDate>Wed, 21 May 2025 10:03:35 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0834</guid></item><item><title>Tunable Stack Architecture for Photonic Crystal OLEDs</title><caseId>C0820</caseId><link>https://uvm.technologypublisher.com/techcase/C0820</link><description>These OLED vertical stacks are low cost, durable and applications in flexible displays, light panels and spectroscopy sensors

Background:

Organic light-emitting diode (OLED) technology brings the promise of sharper displays at lower cost. This sharpness arises from the fact that conventional LEDs leak a little light when displaying black, degrading the contrast ratio of bright-to dark. OLEDs display pure black, with no leaks, leading to an infinite contrast ratio. In addition, OLEDs offer many advantages over LEDs including lower cost, lighter weight, and flexibility. Experts predict the ove...</description><pubDate>Wed, 21 May 2025 10:02:19 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0820</guid></item><item><title>Electric Field-Assisted Forward Osmotic (EFO) Device for Saline Production from Marginal Waters</title><caseId>C0816</caseId><link>https://uvm.technologypublisher.com/techcase/C0816</link><description><![CDATA[Portable EFO device which is easy and low cost to maintain, durable and environmentally friendly with no harsh chemicals needed

Background:

Saline, the lifeblood of all hospital/medical systems, is supplied by only five or fewer companies in the&nbsp;United States. Currently, the United States market for saline is estimated at $3 billion per year and is rising. While saline is inexpensive, supply is restricted due to limitations in the manufacturing and transportation process. Challenges include but are not limited to saline quality problems, insufficient production capacity, a lack of local...]]></description><pubDate>Wed, 21 May 2025 10:01:52 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0816</guid></item><item><title>Preparations of Primary Phosphines</title><caseId>C0790</caseId><link>https://uvm.technologypublisher.com/techcase/C0790</link><description>A clean phosphine synthesis method that circumvents the use of toxic reagents, uses industrially common hydrogen and produces no waste

Background:

Primary phosphines are highly versatile precursors and are used as commercial reagents in industries such as pharmaceutical manufacturers, agriculture (pesticides), and materials science industries (semiconductors). Current production processes use highly hazardous reagents, creating substantial amounts of hazardous waste and low yield (i.e., inefficient). Primary phosphines are currently imported due to these challenges and the types available ar...</description><pubDate>Wed, 21 May 2025 09:56:51 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0790</guid></item><item><title>Endoscopic Dilation Monitor for Esophageal Dysphagia Treatment</title><caseId>C0778</caseId><link>https://uvm.technologypublisher.com/techcase/C0778</link><description>Provides real-time, reproducible pressure data and gives direct control of dilation execution to the physician.

Background:

Endoscopic dilation for esophagal dysphagia is currently empiric and subjective, and without objective predictive data, often results in serial dilation procedures or worse, injury. Data from previous dilations (pressure, volume or pressure/volume curves) can potentially be used to set parameters for subsequent dilations: if the patient does well with the dilation similar parameters from the past dilation can be used, if dilation is ineffective, more aggressive dilation...</description><pubDate>Wed, 21 May 2025 09:55:50 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0778</guid></item><item><title>Using Artificial Intelligence to Detect Endoleaks</title><caseId>C0764</caseId><link>https://uvm.technologypublisher.com/techcase/C0764</link><description>Abdominal aortic aneurysm (AAA) is in the top 20 causes of death in the United States and each year approximately 10,000 deaths are attributed to a ruptured AAA.

Surgery is the only treatment and endovascular abdominal aortic aneurysm repair (EVAR) accounts for over 75% of elective surgeries and an increasing amount of emergency AAA repairs for ruptured AAAs. After EVAR surgery, lifelong surveillance is required and there is a critical unmet need to improve detection of endoleaks as the number of patients and subsequent complications increases. This technology is a machine learning algorithm ...</description><pubDate>Wed, 21 May 2025 09:54:35 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0764</guid></item><item><title>Pooled Neo-Antigen Antibody Treatment for Cancer</title><caseId>C0761</caseId><link>https://uvm.technologypublisher.com/techcase/C0761</link><description>Antibodies are highly capable of initiating cytotoxicity of target cells, but a fundamental unresolved property of antibody treatment of cancer is the heterogeneity of the cancer cell population of the tumor, and subsequent tumor resistance to the treatment. Using multiple cell surface related neo-antigens, each with a single amino-acid change, a cocktail of polyclonal antibodies was developed to address this target heterogeneity and redirect effector immune cells to multiple cancer cell types within the tumor. 

Preliminary in vivo data shows intense and homogenous antibody binding with the p...</description><pubDate>Wed, 21 May 2025 09:54:20 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0761</guid></item><item><title>PAC1R Inhibitors for Treatment of Pain and Stress Related Disorders</title><caseId>C0759</caseId><link>https://uvm.technologypublisher.com/techcase/C0759</link><description>PACAP signaling has been identified in multiple intersecting stress and pain associated pathologies

Background:

The healthcare and loss of productivity costs of pain and stress related disorders now exceed those of cardiovascular disease, cancer and diabetes. More than 65 million adults are affected by anxiety disorders in the United States and Europe alone and healthcare costs in the US exceed $42 billion a year. There are currently few therapeutic options to address this problem and what is available often fails to offer relief or produces undesirable side effects.

Technology Overview:

P...</description><pubDate>Wed, 21 May 2025 09:54:05 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0759</guid></item><item><title>Oscillating-field Assisted Membrane Filtration for Wastewater Phosphorus Recovery</title><caseId>C0754</caseId><link>https://uvm.technologypublisher.com/techcase/C0754</link><description><![CDATA[Pipe descaling technology coupled with an electric-filtration membrane filtration cell, to enhance phosphorus capture and removal

Background:

Most commercial phosphorus removal nutrient solutions are only economically feasible for larger scale applications and are often not financially viable. The Pe-Phlo (pronounced P Flow) is a mobile, flexible and scalable solution for phosphorus capture and removal. Pe-Phlo applications focus on reduced installation and operational costs without the investment needed for conventional phosphorus removal &ldquo;brick and mortar&rdquo; approaches.

Technolo...]]></description><pubDate>Wed, 21 May 2025 09:53:45 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0754</guid></item><item><title>PIP2 Treatment for Small Vessel Disease and Stroke</title><caseId>C0740</caseId><link>https://uvm.technologypublisher.com/techcase/C0740</link><description>Functional and structural attenuations in the cerebral micro vascularization that are early culprits in the manifestations of SVDs

Background:

Cerebral small vessel diseases (SVD) are responsible for more than 25% of ischemic stroke and are a leading cause of age-related cognitive dementia and disability. Despite the enormous impact of SVDs on human health, little is known about disease processes and key biological mechanisms and there are no specific therapeutic treatments of these diseases.

Technology Overview:

Research from the University of Vermont has identified certain functional and...</description><pubDate>Wed, 21 May 2025 09:52:47 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0740</guid></item><item><title>FcγRIIa: A Novel Marker of Cardiovascular Risk</title><caseId>C0729</caseId><link>https://uvm.technologypublisher.com/techcase/C0729</link><description><![CDATA[Increased platelet reactivity has been associated with a greater risk of cardiovascular events. Despite this consistent association, individualized anti-platelet therapy, guided by platelet function testing has not yet shown to reduce the risk of cardiovascular events and intra-individual variability of the current indirect platelet function tests has been identified as the potential contributor to this lack of efficacy.

Fc&gamma;RIIa is expressed on the surface of platelets and amplifies the activation of platelets. Platelet expression of Fc&gamma;RIIa also provides a tangible link between s...]]></description><pubDate>Wed, 21 May 2025 09:51:49 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0729</guid></item><item><title>Multi-Breath Nitrogen Washout Model for Lung Function Determination</title><caseId>C0703</caseId><link>https://uvm.technologypublisher.com/techcase/C0703</link><description><![CDATA[The Lung Clearance Index (LCI) is a lung function parameter derived from the multi-breath washout (MBW) test. Although recent technological advances in equipment design have re-popularized this test, current analysis methods remain empirical and are dependent on the patient being able to breath regularly and deeply. This novel MBW data analysis method overcomes bothlimitations by fitting a multi-compartmental lung model to the exhaled nitrogen concentration profile over the entire duration of the patient&rsquo;s nitrogen expiration for each breath. In addition, the model provides several addit...]]></description><pubDate>Wed, 21 May 2025 09:49:30 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0703</guid></item><item><title>Highly Specific and Neutralizing Therapeutic Antibodies for Zika Virus</title><caseId>C0700</caseId><link>https://uvm.technologypublisher.com/techcase/C0700</link><description><![CDATA[Zika virus, a member of the Flaviviridae virus family, is a single stranded positive sense RNA virus that is spread by Aedesmosquitoes. While it was previously contained to regions of Africa and Asia along a narrow equatorial belt, it has recently spread to areas of the Americas. In adults, Zika virus infection can lead to Guillain-Barre syndrome and fetuses in utero are especially susceptible to Zika virus infections, causing thousands of birth defects and miscarriages. 

Researchers at UVM and UNC have identified two highly specific and neutralizing antibodies isolated from a traveler na&ium...]]></description><pubDate>Wed, 21 May 2025 09:49:23 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0700</guid></item><item><title>Photogrammetric and Multisensor Position Registration for Ground Penetrating Radars</title><caseId>C0697</caseId><link>https://uvm.technologypublisher.com/techcase/C0697</link><description><![CDATA[This innovation utilizes geophysical instruments (i.e., GPR) moving across the ground to figure out what is under the earth&rsquo;s surface. The question involves finding out where the object is located within a centimeter. To overcome the localization or registration challenge, the team turned to the smartphone technology and incorporated photogrammetry tools/capabilities.

The key aspect of this invention relates to being able to visualize the subsurface objects into a 3-D form. This is where the gaming world was incorporated into the invention by leveraging augmented reality (AR) to render ...]]></description><pubDate>Wed, 21 May 2025 09:49:10 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0697</guid></item><item><title>Peritoneal Dialysis Catheter Anchor</title><caseId>C0681</caseId><link>https://uvm.technologypublisher.com/techcase/C0681</link><description>Silastic tubing with encased weighted metallic ball bearings to both position and fix the PD catheter into a satisfactory position

Background:

Peritoneal dialysis (PD) is a low cost and physiologically beneficial option for many patients with end stage renal disease (ESDR), but catheter migration from the cul de sac of the pelvis can lead to catheter malfunction and ultimately require the transfer of the patient to full hemodialysis. Migration is reported in up to 35% of cases, but more recent 3D imaging shows that this frequency is likely severely underestimated and may be closer to 80%. Cu...</description><pubDate>Wed, 21 May 2025 09:47:50 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0681</guid></item><item><title>A Predictive miRNA Signature for Breast Cancer Risk Among High-Risk Women</title><caseId>C0669</caseId><link>https://uvm.technologypublisher.com/techcase/C0669</link><description><![CDATA[Significant limitations exist in the ability to predict breast cancer risk at the individual level in women at high risk of breast cancer.&nbsp; More precise predictions of risk are needed in these populations to ensure that those who will develop cancer take advantage of life saving preventable strategies. Researchers at UVM have identified measurable differences in C-miRNA from the serum of women at risk for breast cancer and who develop tumors and from the serum of women at risk of breast cancer who remain cancer free. From this data, a preliminary 6 miRNA risk signature has been identified...]]></description><pubDate>Wed, 21 May 2025 09:47:02 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0669</guid></item><item><title>Interim Buprenorphine Treatment</title><caseId>C0649</caseId><link>https://uvm.technologypublisher.com/techcase/C0649</link><description>Opioid addiction treatment through a portable device, combined with automated check-ins, in-person testing, and HIV/HepB education

Background:

Opioid addiction in American has hit epidemic levels and despite the demonstrated need for and the effectiveness of current treatments, waitlists persist. While waiting for treatments, patients are at high risk for illicit drug use, engaging in criminal activity, contracting infectious disease, and death.

Technology Overview:

Interim buprenorphine treatment (IBT) offers a comprehensive solution with daily doses administered through a computerized, p...</description><pubDate>Wed, 21 May 2025 09:41:09 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0649</guid></item><item><title>Portable ECMO with Avian Lung Structure</title><caseId>C0646</caseId><link>https://uvm.technologypublisher.com/techcase/C0646</link><description>Current available extracorporeal membrane oxidation (ECMO) units are expensive, not portable and leave patients confined to hospitals and requiring the care of highly trained personnel. With a growing number of end stage lung disease patients and those waiting for lung transplants, there is a critical unmet need for effective, economical and convenient lung assist devices that can be used more widely throughout the health care system.

Using their expertise in lung decellularization and recellularization, UVM researchers are taking advantage of the cross current flow architecture of avian lung...</description><pubDate>Wed, 21 May 2025 09:40:55 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0646</guid></item><item><title>Nano-Biocatalytic Membranes for Water Treatment</title><caseId>C0642</caseId><link>https://uvm.technologypublisher.com/techcase/C0642</link><description>Multi-functional membrane to prevent biofouling during water purification processes

Background:

As the need for more sources of drinkable water increases, there is a strong interest in developing more advanced water purification technologies. During long term use, water purification membranes are susceptible to biofilm formation, clogging the membranes, reducing the effective life of the membrane and putting water supplies at risk.

Technology Overview:

This technology is a multi-functional membrane to prevent biofouling during water purification processes. The membrane is functionalized wi...</description><pubDate>Wed, 21 May 2025 09:40:40 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0642</guid></item><item><title>Identification of Aggressive Papillary Microcarcinomas of the Thyroid</title><caseId>C0639</caseId><link>https://uvm.technologypublisher.com/techcase/C0639</link><description>Background:

The most common type of thyroid cancer is papillary thyroid cancer (PTC) and papillary microcarcinomas (PMC), PTC tumors of less than 1.0 cm, now account for about 40% of all PTC tumors. PMC tumors are thought to be relatively innocuous, however a PMC has an incidence of metastases of 20-50% and currently there is no ability to clearly determine if a PMC is indolent or aggressive at diagnosis. Consequently, many patients undergo surgery and may end up overtreated, increasing morbidity, while others may be undertreated, increasing morbidly from re-operation and worse outcomes.

App...</description><pubDate>Wed, 21 May 2025 09:40:28 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0639</guid></item><item><title>Augmenting Vaccine Viral Production Using Late Domain Manipulation</title><caseId>C0638</caseId><link>https://uvm.technologypublisher.com/techcase/C0638</link><description>Vaccines against infectious disease have dramatically decrease mortality and morbidity in the western hemisphere and have led to the eradication of small pox globally.

Background:

In order to expand this impact, the industry needs increased and improved vaccine development methods. Reduced production time and costs would significantly alter and impact the market for the best and efficacious vaccines, as well as change how the global health community approaches vaccination for both controllable diseases and in preparation for novel threatening vectors.

The Botten lab has identified a late do...</description><pubDate>Wed, 21 May 2025 09:40:22 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0638</guid></item><item><title>DUOX1 Inhibitors for Treatment of Allergic Disorders</title><caseId>C0614</caseId><link>https://uvm.technologypublisher.com/techcase/C0614</link><description>Current treatments for allergic diseases such as asthma, atopic eczema and psoriasis are still not effective for 10% of the millions of patients worldwide with these diseases. Dual oxidase (DUOX1) is a member of the NADPH oxidase family and is a critical mediator of innate immune response to allergens. Several thiol-reactive electrophiles have been identified that inhibit airway allergen response via DUOX1 inhibition and based on this work, selective peptide-based inhibitors have been designed to provide a novel approach to treat patients with allergic asthma or skin disorders, which will serv...</description><pubDate>Wed, 21 May 2025 09:38:40 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0614</guid></item><item><title>Ground Penetrating Radar and Mapping for Underground Infrastructure Maintenance</title><caseId>C0595</caseId><link>https://uvm.technologypublisher.com/techcase/C0595</link><description><![CDATA[This technology uses full waveform digitization of the returning signals to significantly reduce the number of launch signals needed

&nbsp;

Background:

Critical to the identification and repair of crumbling and unstable infrastructure is the use of ground penetrating radar systems to scan below the surface for dangers present. However, the FCC has mandated a limit on emissions by ground penetrating radar systems to prevent them from interfering with other important radio operations and licensed services. To ensure the continued use of this important tool in infrastructure maintenance, UVM r...]]></description><pubDate>Wed, 21 May 2025 09:37:42 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0595</guid></item><item><title>Lupus (SLE) Diagnostic Biomarker and Therapeutic</title><caseId>C0587</caseId><link>https://uvm.technologypublisher.com/techcase/C0587</link><description><![CDATA[Only one new drug has become available over the past 50 years for the estimated 1.5M Americans and 5M people worldwide suffering from systemic lupus erythematosus (SLE), also known as lupus. In addition, SLE is extremely challenging to diagnose, taking an average of 6 years to diagnosis from the first sign of symptoms, delaying critical early treatment.&nbsp;

Background:

UVM researchers identified a previous unknown mechanism involved in the SLE immune response that provides both a novel therapeutic target and a new method of diagnosis and stratification of SLE patients. Mitochondrial antivi...]]></description><pubDate>Wed, 21 May 2025 09:36:58 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0587</guid></item><item><title>Environmentally Responsive Fibers for Reinforced Concrete Composites</title><caseId>C0586</caseId><link>https://uvm.technologypublisher.com/techcase/C0586</link><description>The randomness of the orientation of the ER fibers allows the concrete structure to handle a much more diverse array of stresses.

Background:

Fiber-reinforced concrete composites have become popular in the construction industry due to their robust nature with regard to both compression and tension. These fibers, however, cannot be prestressed or post-tensioned in any practical way with the current standard of technology.

Technology Overview:

University of Vermont researchers have invented a method of efficiently prestressing a reinforced concrete composite using environmentally responsive ...</description><pubDate>Wed, 21 May 2025 09:36:54 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0586</guid></item><item><title>Piperazine Based Lead Compound for Cryptosporidium Reduces Both Diarrhea and Parasites</title><caseId>C0585</caseId><link>https://uvm.technologypublisher.com/techcase/C0585</link><description><![CDATA[Cryptosporidiosis is a leading cause of life-threatening diarrhea for young children and immunocompromised people and&nbsp;Cryptosporidium parvum, one of the two main human&nbsp;Cryptosporidium&nbsp;pathogens, is also an important cause of diarrhea in dairy calves. Despite this impact on both human and animal health, the best available treatment of&nbsp;Cryptosporidium&nbsp;is only modestly efficacious and anti-Cryptosporidium&nbsp;drug development is complicated by the fact that rodents do not get diarrhea from&nbsp;Cryptosporidium&nbsp;strains relevant to humans.

Technology Overview:

Resea...]]></description><pubDate>Wed, 21 May 2025 09:36:50 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0585</guid></item><item><title>Cymanquines: Metallo-Chloroquine Therapeutics</title><caseId>C0578</caseId><link>https://uvm.technologypublisher.com/techcase/C0578</link><description><![CDATA[Inhibition of autophagy has become an attractive target for the clinical management of drug resistant cancers. Towards this end, the potent anti-malarial chloroquine (CQ) has been explored as an autophagy inhibitor in multiple studies. Unfortunately, CQ&rsquo;s inability to exhibit cytotoxic effects in the low PH tumor microenvironment has presented some limitations for this use. 

In response to the limitations of CQ, UVM researchers developed a novel organometallic analog of CQ, cymanquine (CymQ).CymQ displays superior single agent cytotoxicity compared to CQ and other CQ analogs, while main...]]></description><pubDate>Wed, 21 May 2025 09:36:07 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0578</guid></item><item><title>Optimization of ARDS Ventilation with Real-Time Respiratory Mechanics Monitoring</title><caseId>C0538</caseId><link>https://uvm.technologypublisher.com/techcase/C0538</link><description>Diagnostic tool that uses a new mode of mechanical ventilation (variable ventilation) to optimize the management of patients with ARDS

Background:

Currently there are no drugs available for acute respiratory distress syndrome (ARDS), an often fatal condition, and the only treatment consists of supportive therapies, mainly mechanical ventilation. A patient can make a full recovery if they are properly ventilated, but mechanical ventilation can further damage the already injured lung tissue, leading to ventilator induced lung injury (VILI), which often leads to death. There is a need for impro...</description><pubDate>Wed, 21 May 2025 09:33:43 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0538</guid></item><item><title>High Throughput Lung De/Re Cellularization</title><caseId>C0516</caseId><link>https://uvm.technologypublisher.com/techcase/C0516</link><description>Current pre-clinical drug discovery incompletely recapitulates the complexity and heterogeneity of human disease and use of decellularized tissues and organ scaffolds to provide better model systems has drawn great interest, especially in complex organs such as the lung. Acellular lung tissue scaffolds from both normal and diseased human lung tissues provide a more biologically relevant three-dimensional structure that preserves disease phenotypes and bridges the gap between cell culture, animal models and human disease. The Weiss lab, experts in lung regeneration and repair, have developed a ...</description><pubDate>Wed, 21 May 2025 09:31:56 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0516</guid></item><item><title>A Biomarker and Therapeutic Target for Early Onset Preeclampsia Brain Injury</title><caseId>C0489</caseId><link>https://uvm.technologypublisher.com/techcase/C0489</link><description>Major morbidity and mortality associated with preeclampsia occurs as a result of brain injury and neurological complications, such as seizure, and occur more often in early onset preeclampsia (EPE). Researchers at UVM have identified a biomarker that arises in women with EPE and has been shown to increase both blood brain barrier (BBB) permeability and brain inflammation in pregnant mice. The oxidative stress of EPE, combined with pregnancy induced hyperlipidemia, increases circulating oxidized LDL (oxLDL), which disrupts the BBB via LOX-1 binding and the subsequent generation of peroxynitrite...</description><pubDate>Wed, 21 May 2025 09:29:44 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0489</guid></item><item><title>“Cell-Kro”: Priming of Cardiac Stem Cells to Promote Graft Success and Cardiac Regeneration</title><caseId>C0487</caseId><link>https://uvm.technologypublisher.com/techcase/C0487</link><description><![CDATA[A powerful tool that remarkably promotes graft success and lasting cell replacement

Background:

No treatments that preserve or replace damaged tissue after myocardial infarction (MI) currently exist and poor graft success is a common problem after cultured cell transplantation into injured tissues. Cell grafts after ischemic injury, such as MI, are especially inefficient due to low adhesion to host tissue, low cell survival rates, and low levels of migration.

Technology Overview:

&ldquo;Cell-Kro&rdquo; is a CTGF and insulin combo that was identified by University of Vermont researchers as ...]]></description><pubDate>Wed, 21 May 2025 09:29:36 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0487</guid></item><item><title>Cardiopulmonary Function Monitor</title><caseId>C0479</caseId><link>https://uvm.technologypublisher.com/techcase/C0479</link><description><![CDATA[This method causes changes in an individual&rsquo;s blood oxygen saturation which is later measured at a peripheral site using pulse oximetry

Background:

Cardiac output is the most important indicator of cardiac function and is currently measured with invasive heart catheterization or by using time-consuming and expensive methodologies such as echocardiography or magnetic resonance imaging.

Technology Overview:

Researchers at the University of Vermont have conceived a new method to measure circulation time without using injected agents or the need for blood samples. This method is accompli...]]></description><pubDate>Wed, 21 May 2025 09:29:06 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0479</guid></item><item><title>Increase in Vasodilation in Small Vessel Disease Treated with Relaxin</title><caseId>C0470</caseId><link>https://uvm.technologypublisher.com/techcase/C0470</link><description><![CDATA[Hypertension is a major risk factor for cerebral small vessel disease (SVD), a leading cause of progressive cognitive decline and a major risk factor for stroke. In pregnancy, relaxin promotes selective outward remodeling of parenchymal arterioles (PA) and increases capillary density in the brain specifically through the activation of peroxisome proliferator-activated receptor-&gamma; (PPAR&gamma;) The Cipolla lab has found that in rat models of hypertension induced SVD, relaxin enhanced vasodilation by crossing the blood brain barrier, decreasing vascular resistance of PA and increasing blood...]]></description><pubDate>Wed, 21 May 2025 09:28:37 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0470</guid></item><item><title>Redox-based Regulation of Fibrotic Lung Disease and Cancer</title><caseId>C0469</caseId><link>https://uvm.technologypublisher.com/techcase/C0469</link><description>Inhalable and lung-specific treatments to prevent and repair restructuring in fibrotic lung tissue

Background:

Idiopathic Pulmonary Fibrosis (IPF) is a progressive disease for which no effective treatments are available. Current treatment options, pirfenidone and nintedanib have substantial side-effects and do not extend survival. IPF is a disease that is accompanied by oxidative stress, however, generic non-specific antioxidants, such as N-acetyl-cysteine, are not effective

Technology Overview:

The redox systems group at the Vermont Lung Center has identified a new model for epithelial ce...</description><pubDate>Wed, 21 May 2025 09:28:32 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0469</guid></item><item><title>Threonyl-tRNA Synthetase (TARS) – A Novel Target and Biomarker for Metastatic Prostate and Ovarian Cancer</title><caseId>C0460</caseId><link>https://uvm.technologypublisher.com/techcase/C0460</link><description><![CDATA[The aminoacyl-tRNA synthetases (AARS) family catalyzes the attachment of amino acids to tRNAs, but its members have now been found to play significant roles in a number of unique diseases, including autoimmune disorders and cancers. &nbsp;At UVM, researchers have identified a novel pro-angiogenic role for one member of the AARS family, TARS, that is also upregulated in metastatic prostate and ovarian cancers. The researchers have since shown that TARS itself is a pro-angiogentic chemokine-like protein and, in cell models, efficiently stimulates new blood vessel formation. This, together with T...]]></description><pubDate>Wed, 21 May 2025 09:27:53 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0460</guid></item><item><title>A First-in-Class Anti-Hypertensive Therapy</title><caseId>C0454</caseId><link>https://uvm.technologypublisher.com/techcase/C0454</link><description>Synthetic peptides for the treatment of resistant hypertension and acute hypertensive crisis

Background:

Despite the number of available treatments, nearly one-third of the over 73 million patients with hypertension respond poorly to current treatment options. This presents a significant commercial opportunity for new therapies with novel mechanisms of action. The cGMP-dependent protein kinase (PKG) has long been identified as a master regulator of vasodilation and target for drug development, but previous attempts have failed to develop a cGMP-independent activator.

Technology Overview:

R...</description><pubDate>Wed, 21 May 2025 09:27:31 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0454</guid></item><item><title>Visualization of Individual Coagulation Profiles</title><caseId>C0445</caseId><link>https://uvm.technologypublisher.com/techcase/C0445</link><description><![CDATA[Undetected variations in an individual&rsquo;s global hemostasis are risk factors for cardiovascular and neurovascular disease both in therapeutic treatment and in &ldquo;normal&rdquo; situations such as pregnancy and aging.&nbsp; Professor Brummel-Ziedins and her team have developed algorithms to support clinical visualization of individual patient hemostatic profiles allowing evaluation of an individual&#39;s hemorrhage control either during therapeutic treatment or over time in healthy individuals, such as in pregnancy or aging.

Applications:


	Coagulation and hemorrhage management.


Adv...]]></description><pubDate>Wed, 21 May 2025 09:26:59 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0445</guid></item><item><title>Triacetin Treatment as Cancer Adjuvant</title><caseId>C0438</caseId><link>https://uvm.technologypublisher.com/techcase/C0438</link><description>Cancer cells exhibit numerous genetic, epigenetic and metabolic changes and it is this dysregulation that leads to the rapid cell growth of highly malignant cancers, such as glioblastoma multiforme (GBM). The Jaworski lab has identified and tested an FDA approved food additive, triacetin (glyceryl triacetate, GTA) that induces cell growth arrest in GBM cells, while having little to no effect on healthy cells. Further work has shown that GTA functions at the intersection of metabolism and epigenetics, converting to acetyl co-enzyme A, reversing the Warburg effect and promoting acetylation of hi...</description><pubDate>Wed, 21 May 2025 09:26:31 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0438</guid></item><item><title>PACAP and PAC1R Biomarkers for Anxiety and PTSD</title><caseId>C0421</caseId><link>https://uvm.technologypublisher.com/techcase/C0421</link><description>The healthcare and loss of productivity costs of pain and stress related disorders now exceed those of cardiovascular disease, cancer and diabetes. More than 65 million adults are affected by anxiety disorders in the United States and Europe alone and healthcare costs in the US exceed $42 billion a year. Few biological markers have been available for diagnosis of post-traumatic stress disorder (PTSD) making it hard to distinguish from other psychiatric disorders and treat appropriately. In a group of 64 people, most of whom had experienced significant trauma, women with above-average PACAP lev...</description><pubDate>Wed, 21 May 2025 09:25:23 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0421</guid></item><item><title>Sound Processing Software for Improved Audibility of Music/Speech in MRI</title><caseId>C0404</caseId><link>https://uvm.technologypublisher.com/techcase/C0404</link><description>Noise produced by functional MRI machines impedes the audibility of music and speech while also causing distraction. This approach applies a parametric equalizer to increase frequency components in proportion to the acoustic power spectrum of the MRI equipment. Further real time processing attenuates the overall frequency level to prevent over modulation and dynamic range compression to improve audibility. Processing can be applied to both digitally recorded or live audio and improves communication between the patient and the MRI operator. 

Applications:


	MRI equipment.


Advantages:


	Imp...</description><pubDate>Wed, 21 May 2025 09:20:35 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0404</guid></item><item><title>Aeroacoustic Duster</title><caseId>C0396</caseId><link>https://uvm.technologypublisher.com/techcase/C0396</link><description>Precision particle removal from a surface with no physical contact using a bounded vortex and peripheral jets providing streamlines

Background:

Mitigation of dust or particle build up on surfaces is a problem in many industries, especially where the surface being cleaned cannot be damaged, such as optical materials or delicate electronic instruments. In addition, the need for dust mitigation on future moon or Mars exploration missions will be critical where small, charged dust particles cannot only cover and foul equipment, but dust containing particles can be breeding grounds for bacteria, ...</description><pubDate>Wed, 21 May 2025 09:20:09 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0396</guid></item><item><title>Wireless Snowpack Monitoring System</title><caseId>C0366</caseId><link>https://uvm.technologypublisher.com/techcase/C0366</link><description>Snowpack studies are essential for water planning and provide critical data for fields such as agriculture, recreation, and city planning. Until now, the predominant ground-based techniques used for these studies have been manual measurement of snow cores and deployment of large, potentially hazardous antifreeze-filled bladders.

The high cost and snowpack damage associated with both techniques have limited their deployment, especially in complex, challenging, or widespread terrain. This limited deployment can reduce the accuracy of runoff forecasts, as variations in wind, terrain, vegetation,...</description><pubDate>Wed, 21 May 2025 08:42:47 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0366</guid></item><item><title>Breath Biofeedback Video Game</title><caseId>C0191</caseId><link>https://uvm.technologypublisher.com/techcase/C0191</link><description>Breath training and awareness using interactive, breath-controlled video games, with both diagnostic and therapeutic benefit

Background:

Breathing, relaxation and awareness training significantly ameliorates respiratory symptoms and dysfunctional breathing. In spite of these benefits, consistent, safe and effective delivery of breath training is difficult and costly due to the lack of available expertise at an affordable cost, competing priorities of patients and the lack of cost-effective, engaging tools.

Technology Overview:

This system delivers breath training and awareness using intera...</description><pubDate>Wed, 21 May 2025 08:16:42 GMT</pubDate><author>UVMI.Case@uvm.edu</author><guid>https://uvm.technologypublisher.com/techcase/C0191</guid></item></channel></rss>